Hemorrhoids are the pathological condition, often characterized by vasodilatation and inflammation in the rectoanal region, which results in increased vascular permeability and extravasation of inflammatory cytokines in the interstitial spaces. In the present study, croton oil has been used as phlogistic agent for experimental induction of hemorrhoids. Croton oil causes inflammation due to release of inflammatory lipid metabolites such as prostaglandins, leukotrienes, TNF-a, nitric acid and bradykinins. These factors alone or in combination regulates the activation of fibroblasts, endothelial cells, macrophages and newly recruited monocytes, lymphocytes, neutrophils and eosinophils which leads to severe inflammation. It is a well known fact that herbal drugs have been in use since many decades, most probably owing to their lesser side effects and high safety profile for hemorrhoids patients. In view of traditional use of bark of A. ferruginea as an anti-inflammatory and anti-hemorrhoid regimen, we have attempted to evaluate its anti-hemorrhoidal activity through well established scientific methods. As a starting point the hydro¬alcoholic extract of bark of A. ferruginea has been screened for the presence of phytoconstituents and the results confirm the presence of flavonoids (66.6 mg/g RE) and phenolic compounds (438.8 mg/g GAE). Since antioxidant activity of hydroalcoholic extract of bark of A. ferruginea has been already reported by Sowndhararajan et al.,17 and Sowndhararajan et al.,18 it was subjected to anti-hemorrhoidal studies. The researchers have also performed antioxidant activity of bark of A. ferruginea but not stated in the present manuscript.(NEXT : Hemorrhoids Natural Treatment Success Stories)
Herbs Treatment For Hemorrhoids (STUDY)
